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Craniomaxillofacial Implants Market Modest Situation Among the Top Manufacturers

The global craniomaxillofacial implant market was valued at US$ 1,907.9 million in 2016 and is expected to witness a robust CAGR of 6.2% over the forecast period (2017-2025).

 

Craniomaxillofacial is a special branch of orthopedic surgery, which focuses on all the aspects of facial and skull disorders. The craniomaxillofacial implant surgery is carried out to treat a severe injury of facial and cranial bones, where the implants are temporarily or permanently placed in the body. Traumas, accidents, and genetic defects lead to craniomaxillofacial deformities.

Craniomaxillofacial Implants Market Modest Situation Among the Top Manufacturers

Craniomaxillofacial is a special branch of orthopedic surgery, which focuses on all the aspects of facial and skull disorders. The craniomaxillofacial implant surgery is carried out to treat a severe injury of facial and cranial bones, where the implants are temporarily or permanently placed in the body. Traumas, accidents, and genetic defects lead to craniomaxillofacial deformities. Craniomaxillofacial implants surgery is also carried out to correct abnormalities and deformities caused by diseases, such as Crouzon’s disease and Apert’s Syndrome. Initially, the emphasis was just on keeping absolute stability of the bones, without much attention on free movements. However, owing to advancements in technology and implant materials such as biocompatible titanium implants, resorbable plates, screws, and bone grafts, have increased the scope for maintaining stability as well as functionality of the joints, allowing for ease of treatments related to craniomaxillofacial deformities. Furthermore, lack of other alternatives for facial surgeries is expected to favor the craniomaxillofacial implants market. Birth defects such as cleft palate and anotia are also treated through craniomaxillofacial surgeries. According to the Centers for Disease Control and Prevention in the U.S., around 2,650 babies are recorded to be born with a cleft palate, every year. Improvement in implant materials and minimal invasiveness of this type of surgery is increasing its demand among the populace.

Few growth restraining factors are the high costs associated with craniomaxillofacial surgeries and low availability of skilled surgeons.

The global craniomaxillofacial implant market was valued at US$ 1,907.9 million in 2016 and is expected to witness a robust CAGR of 6.2% over the forecast period (2017-2025).

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North America was the dominant region in 2016 and accounted the largest share in the global craniomaxillofacial implants market followed by Europe. The major factor for the dominance of North America in craniomaxillofacial implants market is the high presence of skilled surgeons in the region. According to Center for Disease Control and Prevention in the U.S., around 2 million high school athletes are reported with injuries annually, in which head injuries accounted for 14% each year. Asia Pacific is expected to witness the largest growth rate in the craniomaxillofacial implants market during the forecast period. Factors such as rising expenditure on healthcare by the population and increasing rate of sports-related injuries will augment growth of craniomaxillofacial implants market. Furthermore, old people are prone to higher risk injuries due to their weak skeletal system, and an increasing geriatric pupation will boost the growth of craniomaxillofacial implants market in the near future. According to National Institute on Aging, 524 million people were recorded to be 65 years of age and above in the U.S., accounting for 8% of the world's population in 2010. Also estimates from the same source, by 2050 the population of U.S. will be around 1.5 billion, three times more than in 2010, representing 16% of the world's population.

Improved craniomaxillofacial implant materials and advent of new technologies associated with surgeries are expected to drive the craniomaxillofacial implants market

Patient specific implants, 3D implants, growing demand for bioresorbable materials, and growing adoption of robot assisted surgeries have simplified the complexity of craniomaxillofacial surgeries. Whereas, advanced techniques, including computer-assisted craniofacial reconstruction, distraction osteogenesis, and endoscopic procedures, combined with refinements in surgical equipment such as resorbable plating and distractors, have improved surgical outcomes, while minimizing morbidity. The development of bone graft substitutes with the help of gene therapy and nanotechnology is also expected to drive the craniomaxillofacial implants market.

Some major players operating in the craniomaxillofacial implants market include Stryker Corporation, Johnson & Johnson, Zimmer Biomet Holdings, Inc., Medtronic plc, Integra LifeSciences Holdings Corporation, OsteoMed L.P., Medartis AG, KLS Martin, Calavera Surgical Design, and Matrix Surgicssal USA.

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Multiple Sclerosis Therapeutics Market Research, Growth Opportunities and Forecasts by 2026

Multiple sclerosis (MS) is a demyelinating disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. The disease leads in malfunction of the nervous system to communicate, which in turn causes several signs and symptoms, including physical, mental, and psychiatric problems. Double vision, blindness in one eye, muscle weakness, trouble with sensation, or trouble with coordination are some of the other symptoms. The types of MS include relapsing-remitting MS (RRMS), primary progressive MS (PPMS), and secondary progressive MS (SPMS). RPMS is the most common type characterized by defined attacks with increasing neurological symptoms, PPMS is the rare form characterized by gradual progression of disease, whereas SPMS is commonly identified in people living with relapsed-remitting MS. The most common symptoms of the disease include partial or complete vision loss, prolonged vision loss, lack of coordination, and slurred speech.

A combination of genetic and environmental factors is responsible for the occurrence of the condition. According to a study by International Progressive Alliance, 2013, MS is two to three times more common in women than in men, suggesting that hormones play a significant role in determining susceptibility to the disease.

The global multiple sclerosis therapeutics market was valued at US$ 19.6 billion in 2016 and is expected to witness a robust CAGR of 2.5% over the forecast period (2017 – 2025).

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Multiple sclerosis is a widespread disabling neurological condition, mostly diagnosed in people in the age group 20–50 years. According to the Multiple Sclerosis Foundation, 2017, this autoimmune condition affects 2.5 million people with the global incidence of around 7 cases per 100,000 people per year. The study also states that prevalence rates varies between ethnic and geographical latitudes, ranging from 50 to 120 people per 100,000 population. North America dominates the multiple sclerosis therapeutics market owing to the high prevalence of the condition and the rising economic burden of the disease leading to the adoption of novel therapeutics. According to the Multiple Sclerosis Foundation, 2015, an estimated 400,000 people live with the disease in U.S., and about 200 new cases are diagnosed every week. According to a survey by Healthline Media, 2015, multiple sclerosis ranks second after congestive heart failure with direct and indirect health care costs ranging from US$ 8,528 to US$ 54,244 per patient per year. Higher therapy cost is restraining the growth of the multiple sclerosis therapeutics market.

Intensive R&D programs undertaken by organizations to accelerate the market growth     

Various organizations such as National Institute of Neurological Disorders and Stroke, National MS Society, Parkinson’s Action Network are undertaking extensive efforts to create novel therapies for MS, contributing to be a vital factor driving the growth of global multiple sclerosis therapeutics market. For instance, the scientists at Multiple Sclerosis International Federation are undertaking research to understand, manage and treat the disease and are currently undertaking clinical trials to investigate the potential of stem cell therapies including mesenchymal stem cell (MSCs), hematopoietic stem cells (HSCs) and neural stem cells (NSCs). Also, in 2013, the Progressive MS Alliance was established to specifically research and develop more treatment options for people with the progressive forms of MS which currently has a total of 20 projects with researchers based in nine countries. Additionally, in 2015, the MS Society of Canada and the Canadian Institute of Health Research funded a new research to the University of Alberta to examine novel therapeutic strategy to reduce inflammation in the brain, a key factor contributing to the muscle disability associated with multiple sclerosis.

The major players operating in the global multiple sclerosis therapeutics market include Novartis AG, Teva Pharmaceutical Industries Ltd., Sanofi S.A., Bayer AG, Pfizer, Inc., Biogen Idec, Merck & Co., Inc., and AbbVie, Inc.

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Automated Breast Ultrasound Systems Market Analysis by Developments in Manufacturing Technology

Breast cancer is the most commonly diagnosed type of cancer and the second leading cause of death among women, as evident from stats revealed by the National Breast Cancer Foundation. Growing awareness of breast cancer has increased number of women undergoing breast screening and in turn would propel demand for automated breast ultrasound systems (ABUS) in hospitals and diagnostic centers. ABUS enables physicians to screen women, especially with denser breasts and provides superior image quality, thus providing them a competitive edge over handheld ultrasound systems (HHUS)

The global automated breast ultrasound systems market was valued at US$ 236.5 million in 2015 and is expected to expand at a CAGR of 21.6% during the forecast period (2016 – 2024).

ABUS are approved by the U.S. FDA for screening in conjunction with mammography for dense breasts. Radiologists are inclined towards adoption of ABUS as they provide high quality 3D images. Surgeons are adopting this system for pre-operative evaluation of breast to accurately identify the tumor size and location. HHUS are mainly preferred for preoperative evaluation as compared to ABUS, due to high cost associated with ABUS and lack of skilled radiologists to operate the ABUS system during the crucial preoperative period.

High prevalence of breast cancer and awareness campaigns driving demand for ABUS in developed countries

Factors attributable to the growth of ABUS in North America and European markets include increased patient awareness, high uptake of early breast screening, and availability of funds to install relatively expensive ABUS.

According to the World Health Organization (WHO), 232,924 new cases of breast cancer were diagnosed in 2013. Moreover, the American Cancer Society estimates that until 2016 there are over 2.8 million breast cancer survivors in the U.S.

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According to the Cancer Research UK, the incidence rate of breast cancer in the U.K is expected to rise by 2% from 2014 to 2035

Public Health England launched a campaign called ‘Be Clear on Cancer’ (2015) to raise breast cancer awareness among women over 70 years. Moreover, research and development in the field is encouraged through the Breast Cancer Now Catalyst Programme (2016).

High prevalence coupled with government awareness drives are driving demand for ABUS in the U.S. and U.K.

Increasing awareness programs related to breast cancer driving demand in Asia-Pacific region

Asia-Pacific possess immense revenue potential for the growth of ABUS market. Demand for ABUS in Asia-Pacific in terms of volume is expected to increase at a CAGR of 24.4% during 2016 – 2024. Lack of awareness had deterred the uptake of early breast screening until various cognizance initiatives were undertaken by ABUS manufacturers and non-profit and regional cancer organizations. Some noteworthy initiatives include The Pink Initiative organization in India, Breast Cancer Initiative East Africa Inc. and Pink Ribbon Breakfast initiative by Cancer Australia. Moreover, denser breast tissues in the Chinese population is driving demand for ABUS in China at a rapid pace.

Automated breast ultrasound systems manufacturers are following inorganic strategies to increase their footprint

Inorganic growth roadmap is the key strategy followed by market leaders. For instance, GE Healthcare acquired U-Systems, Inc. in 2014 to expand their breast care innovations portfolio. Philips partnered with SonoCine, Inc. in 2014 to provide ABUS imaging for its ultrasound systems. Hitachi Aloka Medical America, Inc. entered into a strategic alliance with iVu Imaging Corporation in 2014, gaining exclusive distribution rights for iVu’s SOFIA (ABUS) system in North America. This agreement helped iVu Imaging Corporation to get access to the expanded channel and also helped both the companies to leverage the technical expertise of the other which further improved the performance of SOFIA.

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Blow-Fill-Seal Packaging Services in Healthcare Market Upcoming Trends, Demand

The global blow-fill-seal (BFS) packaging services in healthcare market was valued at US$ 240.2 million in 2017 and is expected to witness a robust CAGR of 6.9% over the forecast period (2018–2026).

Blow-Fill-Seal Packaging Services in Healthcare Market Upcoming Trends, Demand

Blow-fill-seal (BFS) is a manufacturing technique used for packaging of injectable solutions, antibiotics, ophthalmological drops, suspensions, infusion solutions, solutions for hemofiltration, and others. In this technique, a container is formed, filled, and sealed, all in one step. It is a type of aseptic packaging system requiring no human intervention. The container can be filled with very low volume (0.1ml) to very large volume (100ml and above) and the configurations of the vials can be changed during the procedure.

Blow-Fill-Seal Packaging Services in Healthcare Market Upcoming Trends, Demand

Blow-fill-seal (BFS) is a manufacturing technique used for packaging of injectable solutions, antibiotics, ophthalmological drops, suspensions, infusion solutions, solutions for hemofiltration, and others. In this technique, a container is formed, filled, and sealed, all in one step. It is a type of aseptic packaging system requiring no human intervention. The container can be filled with very low volume (0.1ml) to very large volume (100ml and above) and the configurations of the vials can be changed during the procedure.

New technologies emerging in blow, fill, and seal manufacturing technique is expected to boost the global blow-fill-seal (BFS) packaging service in healthcare market growth

The introduction of new technologies by key players in the market is expected to increase the demand for blow-fill-seal (BFS) packaging services, which is in turn expected to propel the global blow-fill-seal (BFS) packaging services in healthcare market growth. For instance, in September 2018, Robert Bosch Packaging Technology GmbH introduced a horizontal flow wrapping machine, Sigmapack HML. This machine is used in the last process of blow-fill-seal (BFS) for hermitic sealing of vials. It can seal 350 packages/min. It is designed in a compact size and can be integrated into operation line as well as a standalone system. It also provides ultrasonic sealing for heat-sensitive products. Similarly, in May 2018, Weiler Engineering Inc. developed LAB + ASEP TECH Blow/Fill/Seal (B/F/S) machine. It is designed in a compact size, which allows installation of it in confined spaces. It is designed specifically for laboratories, small scale production, clinical trials, drug shortages, biologics, and vaccines. Such emerging technologies in blow-fill-seal (BFS) is expected to drive the global blow-fill-seal (BFS) packaging services in healthcare market growth.

The global blow-fill-seal (BFS) packaging services in healthcare market was valued at US$ 240.2 million in 2017 and is expected to witness a robust CAGR of 6.9% over the forecast period (2018–2026).

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Acquisitions by the key players in the global blow-fill-seal (BFS) packaging services in healthcare market is expected to have a positive influence on the global blow-fill-seal (BFS) packaging services  in healthcare market growth. For instance, in January 2019, NextPharma, a contract development and manufacturing organization, acquired Santen SA, a contract manufacturing organization, for expansion of its manufacturing facility. It took over all the production facilities of Santen in Tampere, Finland. Furthermore, key players also participate in various conferences and events to showcase their capabilities in the global blow-fill-seal (BFS) packaging services in healthcare market growth. For instance, in May 2018, Rommelag participated in Achema, a world exhibition congress on chemical engineering, environmental protection, and biotechnology. It showcased its blow-fill-seal (BFS) technology in the exhibition. The services offered by Rommelag involves the tailored system configurations, the in-house support for the planning phase of pharmaceutical production, and the after-sales services. Hence, such strategies are expected to drive the global blow-fill-seal (BFS) packaging services in healthcare market growth.

However, presence of alternatives such as aseptic processing (liquids are sterilized thermally and packaged into sterilized containers), which is still used in parenteral applications, is expected to hamper the global blow-fill-seal (BFS) packaging services in healthcare market growth.

Some of the major players operating in the global blow-fill-seal (BFS) packaging services in healthcare market include Recipharm AB, Automatic Liquid Packaging Solutions, Llc, Nephron Pharmaceuticals Corporation, Robert Bosch Packaging Technology GmbH, Catalent, Inc, Horizon Pharmaceuticals, Inc., Unither, ApiJect Systems Corporation, LESVI, and Asept Pak, Inc.

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Nursing Care Services Market– Detailed industry report live covering players

Nursing care services provide special care to patients suffering from chronic diseases such as Parkinson’s disease, Alzheimer’s disease, patients who need care for injury, and who are ill and require continuous attendance. At the nursing care services center, trained professionals provide care facilities such as dressing, personal hygiene, and timely medications. This industry provides patient nursing, rehabilitation services, and living accommodations to people with some disability or chronic disorders.

Quercetin Dihydrate Market Regional Analysis by Distribution Channel

Quercetin is a plant flavonoid found in variety of fruits, vegetables, grains, and leaves. It is used as an ingredient in nutritional supplements and prepared foods. Quercetin dihydrate is formed by removing moisture from quercetin, which is more effective and highly concentrated form of the compound. Quercetin is marketed as a nutritional supplement and helps in reducing inflammation, allergies, and body fat.

Quercetin Dihydrate Market– Drivers

Increasing research activities to identify novel uses of quercetin dihydrate for treating various diseases can be expected to boost growth of the quercetin dihydrate market during forecasted period. For instance, research published in Public Library of Science (PLOS One) Journal in March 2017, reveals that quercetin may be effective in blocking inflammatory compounds released by mast cells during allergic conditions and it is useful in managing allergic rhinitis.

Furthermore, research published in Nutrition Research journal in January 2018 states, quercetin supplementations may boost the antioxidants of body to defend against infections and can be useful in protecting exercise-induced oxidative damage of body. This is attributed to the fact that quercetin supplementation was associated with significant reduction in lipid peroxidation in red blood cells.

Moreover, rising approvals for use of quercetin dihydrate in tablet manufacturing as bulking agent in drug compounding is expected to propel growth of the quercetin dihydrate market during the forecasted year. For instance, in July 2018, U.S. Food and Drug Administration (USFDA) approved quercetin dihydrate as one of the ingredient as a bulk forming agent in the drug compounding.

Quercetin Dihydrate Market– Taxonomy

By Product Type

Powder,Solution

By Application

Atherosclerosis,Chronic Infections,Cosmetics,Nutraceuticals,Allergy & Inflammation

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Quercetin Dihydrate Market– Regional Analysis

On the basis of region, the global quercetin dihydrate market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

North America is projected to be the leading region in the global quercetin dihydrate market during the forecast period due to rising exhibitions of buyers and suppliers from the dietary supplement, beverage, functional food, personal care, and sports nutrition industries. For instance, SupplySide West 2018 organized in November 2018 in the U.S. where, Indena S.p.A. introduced Quercefit. Quercefit was designed for sports nutrition positioning, by using phytosome delivery system. This system allows more bioavailability and high absorption of quercetin.

Key players operating in the quercetin dihydrate market include Sisco Research Laboratories Pvt. Ltd., Hunan Yuantong Pharmaceutical Co., Ltd, TCI Chemicals (India) Pvt. Ltd., Prinova Group LLC., PVP Sociedade Anonima, Baoji Herbest Bio-Tech Co., Ltd., Chengdu Biopurify Phytochemicals Ltd., Apollo Scientific Ltd., and Aceto Corporation.

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Quercetin Dihydrate Market Regional Analysis by Distribution Channel

Furthermore, research published in Nutrition Research journal in January 2018 states, quercetin supplementations may boost the antioxidants of body to defend against infections and can be useful in protecting exercise-induced oxidative damage of body. This is attributed to the fact that quercetin supplementation was associated with significant reduction in lipid peroxidation in red blood cells.

Moreover, rising approvals for use of quercetin dihydrate in tablet manufacturing as bulking agent in drug compounding is expected to propel growth of the quercetin dihydrate market during the forecasted year. For instance, in July 2018, U.S. Food and Drug Administration (USFDA) approved quercetin dihydrate as one of the ingredient as a bulk forming agent in the drug compounding.

Quercetin Dihydrate Market Regional Analysis by Distribution Channel

Moreover, rising approvals for use of quercetin dihydrate in tablet manufacturing as bulking agent in drug compounding is expected to propel growth of the quercetin dihydrate market during the forecasted year. For instance, in July 2018, U.S. Food and Drug Administration (USFDA) approved quercetin dihydrate as one of the ingredient as a bulk forming agent in the drug compounding.

Quercetin Dihydrate Market Regional Analysis by Distribution Channel

Quercetin is a plant flavonoid found in variety of fruits, vegetables, grains, and leaves. It is used as an ingredient in nutritional supplements and prepared foods. Quercetin dihydrate is formed by removing moisture from quercetin, which is more effective and highly concentrated form of the compound. Quercetin is marketed as a nutritional supplement and helps in reducing inflammation, allergies, and body fat.

Quercetin Dihydrate Market Regional Analysis by Distribution Channel

Quercetin is a plant flavonoid found in variety of fruits, vegetables, grains, and leaves. It is used as an ingredient in nutritional supplements and prepared foods. Quercetin dihydrate is formed by removing moisture from quercetin, which is more effective and highly concentrated form of the compound. Quercetin is marketed as a nutritional supplement and helps in reducing inflammation, allergies, and body fat.

Mechanical Ventilators Market Explore Future Growth With Top Players

Mechanical ventilation is a process that helps patients breathe by assisting inhalation of oxygen and exhalation of carbon dioxide through lungs with the help of specialized machines known as mechanical ventilators, respirators or breathing machines. These ventilators are connected to the patients by placing it into the mouth or nose and goes down into the windpipe, whereas some patients undergo surgery to have a hole through which the ventilation pipe can be passed. Mechanical ventilation is a life support treatment that assists the patient with critical health conditions to breathe just enough for the survival. Patients on mechanical ventilators are monitored in an intensive care unit (ICU) settings, which is hooked up to a monitor that measures respiratory rate, blood pressure, heart rate, oxygen saturation, and other critical parameters required for the survival of the patients. The mechanical ventilators does not heal the patient, however, it allows the patient to be stable during the medications and treatments. Healthcare professionals always try to get rid of patients from being monitored on ventilators, as there is a lot of risk involved in it. The process of getting a patient off from the ventilator is termed as weaning.

Market Dynamics

Rising number of admissions in the intensive care units for continuous monitoring of critical and severely ill patients is expected to boost the market growth. For instance, according to the American Association for the Surgery of Trauma, in 2011, 790,257 hospitalizations involving mechanical ventilation were reported. In 2015, the Centers for Disease Control & Prevention (CDC) stated that acute injury and chronic obstructive pulmonary diseases (COPD) are major disorders responsible for ICU admissions. According to the results of Burden of Obstructive Lung Disease (BOLD) 2014, a multinational study to find prevalence of COPD reported that the prevalence of COPD in Germany was 5.9%, 19.1% in South Africa, and 11.9% in Mexico City of the total country’s population. Moreover, the rise in geriatric population suffering from slow recovery process of various chronic diseases is expected to augment growth of the global mechanical ventilators market. For instance, according to the National Council of Aging, in 2014, around 80% of the adults in the U.S. suffer from at least one chronic condition. The rising demand for emergency treatment of prolonged illness is also expected to drive growth of global mechanical ventilators market. However, high costs of the devices and shrinking profit margins of the major market players are expected to hinder the market growth.

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Regional Insights

On the basis of region, the global mechanical ventilators market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa. North America holds a dominant position in the global mechanical ventilators market and is expected to retain its dominance over the forecast period, owing to rising number of patient admissions in emergency wards due to critical health conditions and severe injuries that require external support for survival. For instance, according to the Society of Critical Care Medicine, in 2015, over 5.7 million patients were admitted to the intensive care units (ICU) in the U.S. for intensive or invasive monitoring, airway support, stabilization of chronic medical problems, and breathing disorders.

Furthermore, Asia Pacific is expected to witness a significant growth in the market, owing to developments in healthcare infrastructure, rising awareness among patients and manufacturers, and development of innovative and cost efficient solutions. For instance, in September 2017, the department of Neurology at the All India Institute of Medical Sciences (AIIMS) developed a portable life supporting ventilator that is 450 times smaller than the conventional counterparts and multiple times cheaper than the price of normal mechanical ventilators.

Competitive Insights

The key players operating in the global mechanical ventilators market include Becton, Dickinson & Company, Mindray Medical International Limited, Getinge Group, GE Healthcare, Hamilton Medical AG, Medtronic Plc, Smiths Medical, Draeger Medical GmbH, Philips Respironics, Maquet Medical Systems GmbH, and others. Market players are focused towards providing technologically advanced products to sustain their presence in the market. For instance, in 2016, Maquet Medical Systems introduced two new ventilators named SERVO-U and SERVO-n that provides user-friendly interface to the clinicians dedicated to neonatal intensive care solution.

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Mechanical Ventilators Market Explore Future Growth With Top Players

The rising demand for emergency treatment of prolonged illness is also expected to drive growth of global mechanical ventilators market.

Mechanical Ventilators Market Explore Future Growth With Top Players

Rising number of admissions in the intensive care units for continuous monitoring of critical and severely ill patients is expected to boost the market growth. For instance, according to the American Association for the Surgery of Trauma, in 2011, 790,257 hospitalizations involving mechanical ventilation were reported.